Please use this identifier to cite or link to this item: http://hdl.handle.net/11400/10393
Title: Feature extraction and analysis of prostate cancer proteomic mass spectra for biomarker discovery
Authors: Μπουγιούκος, Παναγιώτης
Κάβουρας, Διονύσης Α.
Δασκαλάκης, Αντώνης
Κοσσίδα, Σοφία
Νικηφορίδης, Γεώργιος Σ.
Contributors: Μπεζεριάνος, Αναστάσιος
Item type: Conference publication
Conference Item Type: Full Paper
Keywords: Biomarkers;Cancer;Βιοδείκτες;Καρκίνος
Subjects: Technology
Biomedical engineering
Τεχνολογία
Βιοϊατρική τεχνολογία
Issue Date: 14-May-2015
2006
Date of availability: 14-May-2015
Abstract: Early detection of cancer is a critical issue for improving patient survival rates. Recent progress in mass spectrometry has shown the promising potential of biomarker discovery in the diagnosis of diseases especially in early stages. In the present study, an alternative approach to feature extraction from mass spectrometry data of prostate cancer is proposed that results in the definition of different biomarkers. The latter provide information rich features that improve the performance of an MLP classifier in differentiating among datasets with different PSA levels of prostate cancer and with no evidence of disease. Prostate cancer dataset was collected from the National Cancer Institute Clinical Proteomics Database. The overall accuracy, in correctly classifying 63 spectra with no evidence of disease (PSA<1) and 69 spectra with prostate cancer (PSA≥4), was 95%. Furthermore 93% was the classification overall accuracy in discriminating 26 spectra of prostate cancer with (4 PSA<10) from 43 spectra of prostate cancer with (PSA>10). The high accuracies obtained by the proposed method might lead to informative biomarkers for early stage of prostate cancer diagnosis.
Language: English
Citation: Bougioukos, P., Cavouras, D., Daskalakis, A., Kossida, S., Nikiforidis, G., et al. (2006). Feature extraction and analysis of prostate cancer proteomic mass spectra for biomarker discovery. In the International Special Topic Conference on Information Technology in Biomedicine (I.T.A.B. 2006). Ioannina ,Greece, 26th-28th October 2006. Available from: http://www.bme.teiath.gr/medisp/pdfs/BOUGIOUKOS_2006_ITAB_Feature%20extraction.pdf
Conference: International Special Topic Conference on Information Technology in Biomedicine
Access scheme: Publicly accessible
License: Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες
URI: http://hdl.handle.net/11400/10393
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