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Title: Blood transfusion improves tissue oxygenation in beta-thalassemia major patients
Authors: Βασιλειάδης, Ιωάννης
Μπάσιος, Νεόφυτος
Γεροβασίλη, Βασιλική
Δημόπουλος, Σταύρος
Λαδής, Βασίλειος
Contributors: Κομπότη, Μαρία
Νανάς, Σεραφείμ Ν.
Item type: Conference publication
Keywords: Near infrared spectroscopy;Blood--transfusion;Thalassemia;Μεσογειακή αναιμία;Οξυγόνωση ιστού;NIRS;Μετάγγιση αιματος;Tissue oxygenation;Beta-thalassemia;β-θαλασσαιμία
Subjects: Medicine
Issue Date: 20-Jul-2014
Date of availability: 20-Jul-2014
Publisher: Μαρβάκη, Χριστίνα
Abstract: Background: Red blood cell (RBC) transfusion is the treatment basis in beta-thalassemia major. Aim: With the present study we aimed to investigate the effect of RBC transfusions on tissue oxygenation, in beta-thalassemics. Microcirculatory indices obtained by Near Infrared Spectroscopy (NIRS) were utilized. Methods: The relative oxyhemoglobin concentration in tissues (StO2), as assessed by NIRS, was measured before and 30 min after a regular transfusion, in 17 consecutive beta-thalassemia major patients. The NIRS probe was placed on the thenar eminence. The oxygen consumption rate (%/min) during a 3 min vascular occlusion and the reperfusion rate after occlusion release were also estimated. Results: The patients received 7.85±1.98 ml/kg packed leukocyte-depleted RBC. StO2 increased significantly after RBC transfusion compared to baseline (90% vs. 88% respectively, p=0.002). Delta StO2 (StO2 change after RBC transfusion) showed a significant negative correlation with baseline StO2. The O2 consumption rate after occlusion showed no significant change after RBC transfusion, while the reperfusion rate displayed an increasing trend of borderline significance (p=0.076). Conclusion: The present study indicates that regular RBC transfusions improve microcirculation in beta-thalassemia major patients.
Description: Research article
Language: English
Citation: Vasileiadis, I., Basios, N., Gerovasili, V. & Dimopoulos, S. (December 2013). Blood transfusion improves tissue oxygenation in beta-thalassemia major patients. “Health Science Journal”. 7(4):448-455.
Journal: Health Science Journal
Type of Journal: With a review process (peer review)
Access scheme: Publicly accessible
License: Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες
Appears in Collections:Τόμος 7, τεύχος 4 (Οκτ. - Δεκ. 2013)

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