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Title: Abnormal P600 in heroin addicts with prolonged abstinence elicited during a working memory test
Authors: Παπαγεωργίου, Χαράλαμπος
Λιάππας, Ιωάννης Α.
Ασβεστάς, Παντελής Α.
Βάσιος, Χρήστος
Ματσόπουλος, Γεώργιος Κ.
Contributors: Νικολάου, Χρυσούλα
Νικήτα, Κωνσταντίνα Σ.
Ουζούνογλου, Νικόλαος Κ.
Ραμπαβίλας, Ανδρέας Δ.
Item type: Journal article
Keywords: Abstinence;Heroin abuse;Αποχή;Εξάρτηση από την ηρωίνη
Subjects: Medicine
Issue Date: 13-Jan-2015
Publisher: Lippincott Williams & Wilkins
Abstract: The P600 component of event-related potentials, believed to be generated by anterior cingulate gyrus and basal ganglia, is considered as an index of aspects of second-pass parsing processes of information processing, having much in common with working memory (WM) systems. Moreover, dysfunction of these brain structures as well as WM deficits have been implicated in the pathophysiology of opioid addicts. The present study is focused on P600 elicited during a WM test in twenty heroin addicts with prolonged abstinence compared with an equal number of healthy controls. The results showed significantly prolonged latencies at right hemisphere, specifically at Fp2 abduction. Moreover, memory performance of patients did not differ from that of normal controls. These findings may indicate that abstinent heroin addicts manifest abnormal aspects of second-pass parsing processes as are reflected by the P600 latencies, elicited during a WM test. Additionally, the P600 might serve as a valuable investigative tool for a more comprehensive understanding of the neurobiological substrate of drug abuse.
Language: English
Citation: Papageorgiou, C., Liappas, I., Asvestas, P., Vasios, C., Matsopoulos, G., et al. (June 2001). Abnormal P600 in heroin addicts with prolonged abstinence elicited during a working memory test.Neuroreport: Cognitive Neuroscience And Neuropsychology. 12(8). pp. 1773-1778. Lippincott Williams & Wilkins.
Journal: Neuroreport: Cognitive Neuroscience And Neuropsychology
Type of Journal: With a review process (peer review)
Access scheme: Embargo
License: Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες
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