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Title: Impaired P600 in neuroleptic naive patients with first-episode schizophrenia
Authors: Παπαγεωργίου, Χαράλαμπος
Κονταξάκης, Βασίλειος Π.
Χαβάκη-Κονταξάκη, Μπεάτα Ι.
Σταμούλη, Σοφία
Βάσιος, Χρήστος
Contributors: Ασβεστάς, Παντελής Α.
Ματσόπουλος, Γεώργιος Κ.
Κοντοπαντελής, Ευάγγελος
Ραμπαβίλας, Ανδρέας Δ.
Ουζούνογλου, Νικόλαος Κ.
Χριστοδούλου, Γεώργιος Ν.
Item type: Journal article
Keywords: First-episode schizophrenia;Short-term memory;Πρώτο επεισόδιο σχιζοφρένειας;Εργασία μνήμης
Subjects: Medicine
Issue Date: 14-Jan-2015
Publisher: Lippincott Williams & Wilkins, Inc
Abstract: Deficits of working memory (WM) are recognized as an important pathological feature in schizophrenia. Since the P600 component of event related potentials has been hypothesized that represents aspects of second-pass parsing processes of information processing, and is related to WM, the present study focuses on P600 elicited during a WM test in drug-naive first-episode schizophrenics (FES) compared to healthy controls. We examined 16 drug-naive first-episode schizophrenic patients and 23 healthy controls matched for age and sex. Compared with controls schizophrenic patients showed reduced P600 amplitude on left temporoparietal region and increased P600 amplitude on left occipital region. With regard to the latency, the patients exhibited significantly prolongation on right temporoparietal region. The obtained pattern of differences classified correctly 89.20% of patients. Memory performance of patients was also significantly impaired relative to controls. Our results suggest that second-pass parsing process of information processing, as indexed by P600, elicited during a WM test, is impaired in FES. Moreover, these findings lend support to the view that the auditory WM in schizophrenia involves or affects a circuitry including temporoparietal and occipital brain areas.
Language: English
Citation: Papageorgiou, C., Kontaxakis, V., Kontaxaki-Havaki, B., Stamouli, S. and Vasios, C. (September 2001). Impaired P600 in neuroleptic naive patients with ®rst-episode schizophrenia. Neuroreport: Cognitive Neuroscience And Neuropsychology. 12(13). pp. 2801-2806. Lippincott Williams & Wilkins, Inc
Journal: Neuroreport: Cognitive Neuroscience And Neuropsychology
Type of Journal: With a review process (peer review)
Access scheme: Embargo
License: Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες
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