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Title: Nasal drug delivery in pharmaceutical and biotechnology
Alternative title / Subtitle: Νερατζής, Ηλίας
Authors: Putheti, Ramesh R.
Patil, Mahesh C.
Obire, Omokaro
Item type: Conference publication
Keywords: Parenteral route;Παρεντερική οδός;Nasal drug delivery;Pharmaceutical and biopharmaceutical;Drug delivery;Ρινική χορήγηση φαρμάκου;Φαρμακευτική και βιοφαρμακευτική;Διανομή φαρμάκου
Subjects: Medicine
Issue Date: 28-Jan-2015
Date of availability: 28-Jan-2015
Publisher: Εκδόσεις ΤΕΙ Αθήνας
Σιανούδης, Ιωάννης
Abstract: For many years, drugs have been administered intranasally for their local effect on the mucosa ( e.g. Antihistamines, decongestant, vasoconstrictors and antibiotics). In more recent years many drugs have been shown to achieve a better systemic bioavailability by self medication through the nasal route than by oral administration. Some of them have been shown to duplicate the plasma profile as i.v. administration. More recently the intranasal route has aroused increasing interest as means of the systemic administration of vaccine, hormones, peptides and certain other drugs. Although traditional nasal drug delivery methods offer significant advantages over injection or oral administration, they face challenges that limit efficacy and applications. Once relegated to treating conditions such as nasal congestion and rhinitis, intranasal drug delivery is now gaining attention for administration of a wide range of pharmaceuticals. Pharmaceutical industries are looking at nasal drug-delivery options as a viable alternative to traditional routes of administration for systemic drugs. This is due to the high permeability of the nasal epithelium, allowing a higher molecular mass cut-off at approximately 1000 Da, and the rapid drug absorption rate with plasma drug profiles sometimes almost identical to those from intravenous injections. In this review, discuss the history of overall nasal drug delivery in the pharmaceutical and biotech industries at present and suggestions for the future.
Language: English
Citation: Putheti, R.R., Patil, M.C. and Obire, O. (2009). Nasal drug delivery in pharmaceutical and biotechnology: present and future. "e-Journal of Science & Technology". [Online] 4(3): 1-21. Available from:
Journal: e-Περιοδικό Επιστήμης & Τεχνολογίας
e-Journal of Science & Technology
Type of Journal: With a review process (peer review)
Access scheme: Publicly accessible
License: Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες
Appears in Collections:Τόμος 04, τεύχος 3 (2009)

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