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Title: Systemic lupus erythematosus and epigenetics
Authors: Ρέγκλη, Αρετή
Κωνσταντινίδης, Πολύδωρος Ι.
Μαλλής, Παναγιώτης
Μάτσης, Κωνσταντίνος
Κωνσταντινίδης, Ιωάννης
Contributors: Κόλλια, Παναγούλα
Item type: Conference publication
Keywords: Autoimmune inflammatory disease;Αυτοάνοση φλεγμονώδης νόσος;SLE;Epigenetics;HATS;HDACS;Επιγενετική
Subjects: Science
Issue Date: 29-Jan-2015
Date of availability: 29-Jan-2015
Publisher: Νερατζής, Ηλίας
Σιανούδης, Ιωάννης
Abstract: Human systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease characterized by autoantibodies to nuclear components with subsequent complex formation and deposition in multiple organs. A combination of genetic and environmental factors is required for disease development1. Apoptotic defects and impaired removal of apoptotic cells contribute to an overload of autoantigens that become available to initiate an autoimmune response2. Epigenetic factors have significant effects on T-cell functions by modulating its DNA methylation pattern and in patients with active lupus happens gene-specific DNA methylation. Also IL-2 contribute in the pathogenesis by reason of IL-2 regulate the tolerance mechanisms such as the activation induced cell death (AICD) and the induction and maintenance of regulatory T-cells3. DNA hypomethylation in CD4+ T-cells causes several gene activations and molecule overexpressions that alters cellular function. Moreover, histone deacetylase inhibitors reverse the skewed expression of multiple genes involved in SLE2. 5-azacytidine and other demethylating agents could induce lupus-like autoimmunity in vitro and in vivo. SLE is a predominantly female disease that affects more the female than the male. The etiology of SLE remains incompletely understood, although a number of genetic and environmental factors have been implicated, that may alter epigenetic regulation of gene expression. Epigenetics refers to heritable chromatin-based mechanisms in the regulation of gene expression without changing the DNA sequence. These mechanisms include DNA methylation, histone modification, abnormalities in ERK pathway signaling, and IL-2 transcriptional irregularity may be the key players through changes on gene expression in the development of this autoimmune disorder.
Language: English
Citation: Regkli, A., Konstadinedes, P.I., Mallis, P., Matsis, K., Constadinides, I., et al. (2009). Systemic lupus erythematosus and epigenetics. "e-Journal of Science & Technology". [Online] 4(4): 75-87. Available from:
Journal: e-Περιοδικό Επιστήμης & Τεχνολογίας
e-Journal of Science & Technology
Type of Journal: With a review process (peer review)
Access scheme: Publicly accessible
License: Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες
Appears in Collections:Τόμος 04, τεύχος 4 (2009)

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