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Title: Formation and statistical optimization of the time controlled pulsatile release propanolol hydrochloride compressed coated tablet
Authors: Prajapati, Bhupendra G.
Patel, Girish N.
Solanki, H. K.
Item type: Conference publication
Keywords: Propranolol hydrochloride;Υδροχλωρική προπανολόλη;Time controlled pulsatile release;Compression coating;Χρόνος ελεγχόμενης παλμικής αποδέσμευσης;Συμπιεστική επικάλυψη;Hydroxypropyl methylcellulose;Υδροξυπροπυλομεθυλοκυτταρίνη;Ethylcellulose;Αιθυλοκυτταρίνη
Subjects: Medicine
Issue Date: 30-Jan-2015
Date of availability: 30-Jan-2015
Publisher: Νερατζής, Ηλίας
Σιανούδης, Ιωάννης
Abstract: The Purpose of present investigation was to evaluate statical influence different concentration of hydroxy propyl methyl cellulose K4M and ethyl cellulose on Propranolol hydrochloride release compression coated tablet using 32 full factorial design. Tablets were prepared by direct compression technique. Time controlled pulsatile Propranolol hydrochloride tablets containing 40 mg of Propranolol hydrochloride were developed using different ratio of hydroxypropyl methylcellulose and ethyl cellulose that retard the drug release in the physiological environment of stomach and 2-3 hr in intestine. Formulation was optimized on basis of acceptable tablet properties and in vitro drug release. To analyse the release mechanism of optimize batch zero order, first order, Higuchi, Hixson Crowell, Korsmeyer–Peppas kinetic model were used. The kinetics release of optimize batch F3 was best explained by zero order model, Hixson Crowell, and Korsmeyer–Peppas kinetic model.
Language: English
Citation: Prajapati, B.G., Patel, G.N. and Solanki, H.K. (2010). Formation and statistical optimization of the time controlled pulsatile release propanolol hydrochloride compressed coated tablet. "e-Journal of Science & Technology". [Online] 5(4): 9-19. Available from:
Journal: e-Περιοδικό Επιστήμης & Τεχνολογίας
e-Journal of Science & Technology
Type of Journal: With a review process (peer review)
Access scheme: Publicly accessible
License: Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες
Appears in Collections:Τόμος 05, τεύχος 4 (2010)

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