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Title: Formation, evaluation and optimization of orally disintegrating tablet of Cinnarizine
Authors: Prajapati, Bhupendra G.
Patel, Satish N.
Item type: Conference publication
Keywords: Water absorption ratio;Αναλογία απορρόφησης νερού;Cinnarizine;Orally disintegrating tablet;Wetting time;Κινναριζίνη;Χρόνος διαβροχής;Στοματικό διαλυόμενο δισκίο
Subjects: Medicine
Issue Date: 1-Feb-2015
Date of availability: 1-Feb-2015
Publisher: Νερατζής, Ηλίας
Σιανούδης, Ιωάννης
Abstract: Objective of this study was to formulate directly compressible orally disintegrating tablets of Cinnarizine with sufficient mechanical integrity, content uniformity, and acceptable palatability to assist patients of any age group for easy administration. Effect of varying concentrations of different superdisintegrants such as crospovidone, croscarmellose sodium, and sodium starch glycolate on disintegration time was studied. Tablets were evaluated for weight variation, thickness, hardness, friability, taste, drug content, in vitro disintegrating time and in vitro drug release. Other parameters such as wetting time, water absorption ratio (‘R’), and drug-excipient compatibility were also evaluated. The disintegration time of the optimized CP5 batch was 25 sec. Good correlation was observed between disintegration time and water absorption ratio (R) for each of three superdisintegrants at concentrations studied. Considering the ‘R’ values and disintegration time, crospovidone was significantly superior compared to other two superdisintegrants tested. Release of drug was faster from formulations containing 6% crospovidone (CP5) compared to the marketed convetional Cinnarizine tablet. Differential scanning calorimetric studies did not indicate any excipient incompatibility, either during mixing or after compression. Finally concluded that directly compressible orally disintegrating tablets of cinnarizine with lower friability, acceptable taste, and shorter disintegration times were obtained using crospovidone at optimized concentrations.
Language: English
Citation: Prajapati, B.G. and Patel, S.N. (2010). Formation, evaluation and optimization of orally disintegrating tablet of Cinnarizine. "e-Journal of Science & Technology". [Online] 5(5): 9-21. Available from:
Journal: e-Περιοδικό Επιστήμης & Τεχνολογίας
e-Journal of Science & Technology
Type of Journal: With a review process (peer review)
Access scheme: Publicly accessible
License: Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες
Appears in Collections:Τόμος 05, τεύχος 5 (2010)

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