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Title: Formulation and evaluation of sustained release matrix tablet of tizanidine hydrochloride by direct compression technique
Authors: Patel, Rakesh P.
Patel, Mehul H.
Prajapati, Bhupendra G.
Baria, Ashok H.
Item type: Conference publication
Keywords: Glyceryl;Γλυκερύλιο;Tizanidine hydrochloride;Sustained release matrix tablet;Υδροχλωρική τιζανιδίνη;Δισκίο παρατεταμένης αποδέσμευσης μήτρας
Subjects: Medicine
Issue Date: 1-Feb-2015
Date of availability: 1-Feb-2015
Publisher: Νερατζής, Ηλίας
Σιανούδης, Ιωάννης
Abstract: The objective of this study was to formulate and evaluate of sustained release matrix tablet of Tizanidine Hydrochloride by direct compression technique. Tizanidine hydrochloride tablets were prepared by melt direct compression technique using xanthum gum, guar gum, Glyceryl behenate, Glyceryl monostearate and Stearic acid in different proportion. Formulated sustain release tablets were evaluated for appearance, dimensions (diameter and thickness), weight variation, hardness, friability, drug content and in-vitro release of Tizanidine hydrochloride. Optimized batch was compared with marketed preparation. The result indicated the formulation containing Glyceryl behenate (30%) showed the release profile similar to marketed preparation with satisfactory physical properties of tablet. It is feasible to formulate sustained release tablet of Tizanidine hydrochloride with acceptable physical properties which could be amenable to replication on an industrial scale.
Language: English
Citation: Patel, R.P., Patel, M.H., Prajapati, B.G. and Baria, A.H. (2011). Formulation and evaluation of sustained release matrix tablet of tizanidine hydrochloride by direct compression technique. "e-Journal of Science & Technology". [Online] 6(1): 69-81. Available from:
Journal: e-Περιοδικό Επιστήμης & Τεχνολογίας
e-Journal of Science & Technology
Type of Journal: With a review process (peer review)
Access scheme: Publicly accessible
License: Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες
Appears in Collections:Τόμος 06, τεύχος 1 (2011)

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