Please use this identifier to cite or link to this item: http://hdl.handle.net/11400/5410
Title: Formulation and in-vitro evaluation of microbially triggered colon specific drug delivery using sesbania gum
Authors: Patel, Girish N.
Patel, R. B.
Patel, H. R.
Item type: Conference publication
Keywords: Metronidazole;Μετρονιδαζόλη;Sesbania gum;Microbially triggered;Compression coated
Subjects: Medicine
Medical physics
Ιατρική
Ιατρική φυσική
Issue Date: 2-Feb-2015
2011
Date of availability: 2-Feb-2015
Publisher: Νερατζής, Ηλίας
Σιανούδης, Ιωάννης
Abstract: The aim of the present study is to develop colon targeted drug delivery systems for metronidazole using sesbania gum as a carrier. Matrix, enteric coated and compression coated tablets of metronidazole containing various proportions of sesbania gum were prepared. All the formulations were evaluated for the hardness, drug content uniformity, and were subjected to in vitro drug release studies. Matrix tablets and enteric coated tablets of metronidazole released 41–71% and 25–28% of the metronidazole, respectively, in the physiological environment of stomach and small intestine depending on the proportion of sesbania gum used in the formulation. Both the formulations failed to control the drug release within 5 hr. The compression coated formulations (CS2) released less than 5% of metronidazole in the physiological environment of stomach and small intestine. When the dissolution study was continued in simulated colonic fluids, the compression coated tablet with 150 mg of sesbania gum coat released another 76% of metronidazole after degradation by colonic bacteria at the end of 12 hr.
Language: English
Citation: Patel, G.N., Patel, R.B. and Patel, H.R. (2011). Formulation and in-vitro evaluation of microbially triggered colon specific drug delivery using sesbania gum. "e-Journal of Science & Technology". [Online] 6(2): 33-45. Available from: http://e-jst.teiath.gr/
Journal: e-Περιοδικό Επιστήμης & Τεχνολογίας
e-Journal of Science & Technology
Type of Journal: With a review process (peer review)
Access scheme: Publicly accessible
License: Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες
URI: http://hdl.handle.net/11400/5410
Appears in Collections:Τόμος 06, τεύχος 2 (2011)

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