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Title: Evaluation and optimization of combined gum mixture as matrix former biomaterial in drug delivery
Authors: Singh, Akhilesh V.
Item type: Conference publication
Keywords: Diclofenac sodium;Νατριούχος δικλοφενάκη;Ghatti gum;Konjac glucomannan;FT-IR;Γλυκομαννάνη Konjac
Subjects: Medicine
Issue Date: 2-Feb-2015
Date of availability: 2-Feb-2015
Publisher: Νερατζής, Ηλίας
Σιανούδης, Ιωάννης
Abstract: In the present investigation, two novel gum mixtures were evaluated as controlled release polymer. The ghatti gum obtained from Anogeissus latifolia and Konjac glucomannan from Amorphophallus konjac was evaluated as base polymer for controlled delivery of model drug diclofenac sodium. The prepared synergistically acting gums were evaluated for compatibility study using FT-IR. The diclofenac sodium tablets were evaluated for hardness, friability, weight variation and drug content. The in vitro dissolution study confirmed that the controlled release behavior is mainly due to konjac glucomannan proportion and optimum concentration ratio for ghatti: konjac glucomannan was 30:70.
Language: English
Citation: Singh, A.V. (2011). Evaluation and optimization of combined gum mixture as matrix former biomaterial in drug delivery. "e-Journal of Science & Technology". [Online] 6(2): 95-99. Available from:
Journal: e-Περιοδικό Επιστήμης & Τεχνολογίας
e-Journal of Science & Technology
Type of Journal: With a review process (peer review)
Access scheme: Publicly accessible
License: Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες
Appears in Collections:Τόμος 06, τεύχος 2 (2011)

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