Please use this identifier to cite or link to this item: http://hdl.handle.net/11400/5943
Title: In vitro and invivo drug-drug interaction study between ketotifen fumerate and chlorpheniramine maleate at gastric and intestinal pH
Authors: Sayeed, Mohammed Aktar
Rana, Sohel
Item type: Conference publication
Keywords: Ketotifen fumerate;Chlorpheniramine maleate;Job's method;Ardon's method;Stability constant values;Μηλεϊνική χλωροφαινιραμίνη;Μέθοδος του Ιώβ;Μέθοδος του Ardon
Subjects: Medicine
Pharmacy
Ιατρική
Φαρμακευτική
Issue Date: 9-Feb-2015
2013
Date of availability: 9-Feb-2015
Publisher: Νερατζής, Ηλίας
Σιανούδης, Ιωάννης
Abstract: The use of two or more drugs in the same prescription is a common practice for the treatment of a patient, which may sometimes be neither safe nor effective. The main aim of the present study was to find out invitro and invivo drug- drug interaction study between ketotifen fumerate and chlorpheniramine maleate in aqueous media at various pH (1.2, 2.8 and 6.8) by using Job‟s continuous-variation analysis and Ardon‟s spectrophotomeric methods. The stability constant values of chlorpheniramine with ketotifen were determined at a fixed temperature (37 0C) at both gastric and intestinal pH. The stability constant values , ranging between 7.79 and 8.21 when ketotifen fumerate and chlorpheniramine maleate were the drug of choice, were derived from Ardon‟s plot as a result of interaction between the drugs, were comparatively stable. However, after interaction it was observed that, stability constant values were more than 1 at both gastric pH (1.2 and 2.8) and intestinal pH (6.8). The in vivo study indicate that the decrease in concentration of ketotifen after concurrent administration of ketotifen and chlorpheniramine was statistically insignificant.
Language: English
Citation: Sayeed, M.A. and Rana, S. (2013). In vitro and invivo drug-drug interaction study between ketotifen fumerate and chlorpheniramine maleate at gastric and intestinal pH. "e-Journal of Science & Technology". [Online] 8(2): 17-25. Available from: http://e-jst.teiath.gr/
Journal: e-Journal of Science & Technology
e-Journal of Science & Technology
Type of Journal: With a review process (peer review)
Access scheme: Publicly accessible
License: Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες
URI: http://hdl.handle.net/11400/5943
Appears in Collections:Τόμος 08, τεύχος 2 (2013)

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