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Title: Application of high performance liquid chromatography to the analysis of cilazapril in bulk and pharmaceutical formations
Authors: Lavudu, Petikam
Rani, Avula Prameela
Sekaran, Chandra Bala
Item type: Conference publication
Keywords: Cilazapril;Cyano column;HPLC analysis;Pharmaceutical formulations;Σιλαζαπρίλη;Φαρμακευτικές συνθέσεις
Subjects: Medicine
Issue Date: 17-Feb-2015
Date of availability: 17-Feb-2015
Publisher: Νερατζής, Ηλίας
Σιανούδης, Ιωάννης
Abstract: A rapid, selective, precise and accurate high-performance liquid chromatography method for the estimation of cilazapril (CZP) in bulk and pharmaceutical formulations has been developed and validated. The assay of the cilazapril was performed on a Cyano Column (150 mm x 4.6 mm, 5 μm particle size) with UV detection at 212 nm. The mobile phase consists of a formate buffer (pH 3.75)-acetonitrile (60:40 v/v) and a flow rate of 1 ml/min was maintained. The calibration curve was linear over the range of 2–200 μg/ml (r 2 = 0.9990). The proposed method was validated as per International Conference on Harmonization guidelines. The proposed method was successfully applied to the quantification of (CZP) in pharmaceutical formulations. The proposed method will be useful for routine quality control analysis of (CZP).
Language: English
Citation: Lavudu, P., Rani, A.P. and Sekaran, C.B. (2014). Application of high performance liquid chromatography to the analysis of cilazapril in bulk and pharmaceutical formations. "e-Journal of Science & Technology". [Online] 9(5): 137-146. Available from:
Journal: e-Περιοδικό Επιστήμης & Τεχνολογίας
e-Journal of Science & Technology
Type of Journal: With a review process (peer review)
Access scheme: Publicly accessible
License: Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες
Appears in Collections:Τόμος 09, τεύχος 5 (2014)

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