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Title: Formulation and in-vitro evaluation of oral sustained release drug delivery system for lamivudine matrix tablets using Methocel K15M CR polymer
Authors: Rahman, Mofizur
Ahsan, Qamrul
Khalipha, Abul Bashar Ripon
Azad, A. K.
Nazneen, Ahmeda Sultana
Contributors: Hossain, Sophia
Haque, Sanjida
Item type: Conference publication
Keywords: Lamivudine;Methocel K15M CR;Matrix tablets;Sustained release;Λαμιβουδίνη;Παρατεταμένη αποδέσμευση
Subjects: Medicine
Issue Date: 18-Feb-2015
Date of availability: 18-Feb-2015
Publisher: Νερατζής, Ηλίας
Σιανούδης, Ιωάννης
Abstract: The present work reports the study of different proportion of Lamivudine: Methocel K15M formulations, in order to investigation the effect of polymer proportion and diluent on the drug release mechanism. Lamivudine, an anti-HIV agent, was used as a model drug to evaluate its release characteristics from different matrices. Matrix tablets of Lamivudine were prepared by direct compression process using methocel K15M CR polymer. In vitro release studies were performed using US Pharmacopeia type 1 apparatus (basket method) in 900 mL of pH 6.8 phosphate buffer at 100 rpm for 8 hours (Initial 2 hours in simulated gastric fluid (pH 1.2)). Scanning Electron Microscopy (SEM) was used to evaluate and surface properties of the matrices. Drug release was analyzed according to their kinetic models. A one-way analysis of variance (ANOVA) was used to interpret the results. Statistically significant differences were found among the drug release profile from different formulations. Higher proportion of polymeric content (25 to 30% of the total tablet weight) in the matrix, release was extended > 8 hours due to increased tortuosity and decreased porosity. At lower proportion of polymeric content (10% of the total tablet weight), the rate of drug release was elevated. Two formulations showed drug release is more controlled. The release mechanism was explored and explained with zero order, first order, Higuchi and Korsmeyer and Hixon-Crowell equations. The results generated in this study showed that the profile and kinetics of drug release were functions of polymer type, polymer level and physico-chemical properties of the drug. By suitable modulation could be developed controlled delivery of such type of drug.
Language: English
Citation: Rahman, M., Ahsan, Q., Khalipha, A. B. R., Azad, A. K. & Nazneen, A. S. (2015) Formulation and in-vitro evaluation of oral sustained release drug delivery system for lamivudine matrix tablets using Methocel K15M CR polymer. "e-Journal of Science & Technology". [Online] 10(1). p. 53-63. Available from: [Accessed 18-02-2015]
Journal: e-Περιοδικό Επιστήμης & Τεχνολογίας
e-Journal of Science & Technology
Type of Journal: With a review process (peer review)
Access scheme: Publicly accessible
License: Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες
Appears in Collections:Τόμος 10, τεύχος 1 (2015)

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