Please use this identifier to cite or link to this item: http://hdl.handle.net/11400/9908
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dc.contributor.authorΣούλπη, Κλεοπάτραell
dc.contributor.authorΚαρίκας, Γεώργιος-Αλβέρτοςell
dc.contributor.authorΜπαρτζελιώτου, Αναστασίαell
dc.contributor.authorΠαπακωνσταντίνου, Ευάγγελος Δ.ell
dc.contributor.authorΚαλογεράκου, Μαρίαell
dc.date.accessioned2015-05-08T00:08:50Z-
dc.date.available2015-05-08T00:08:50Z-
dc.date.issued2015-05-08-
dc.date.issued2007-11-
dc.identifier.citationSchulpis, K.H., Karikas, G.A., Bartzeliotou, A., Papakonstantinou, E.D., Kalogerakou, M. et al. (2007) The effect of diet on Paraoxonase 1/Arylesterase activities in patients with disorders of galactose metabolism. Clinical Endocrinology. [Online] 67 (5). pp.687-692. Available from: http://onlinelibrary.wiley.com [Accessed 07/05/2015]eng
dc.identifier.urihttp://hdl.handle.net/11400/9908-
dc.language.isoeng-
dc.rightsΑναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.sourcehttp://onlinelibrary.wiley.com/doi/10.1111/j.1365-2265.2007.02946.x/abstracteng
dc.subjectεπιδράσεις της δίαιτας-
dc.subjectαντιαρτηριοσκληρωτικό ένζυμο-
dc.subjectΠαραοξονάση-
dc.subjectΑρυλεστεράση-
dc.subjectμεταβολισμός-
dc.subjectγαλακτόζη-
dc.subjecteffects of diet-
dc.subjectantiatherogenic enzyme-
dc.subjectParaoxonase-
dc.subjectarylesterase-
dc.subjectmetabolism-
dc.subjectgalactose-
dc.titleThe effect of diet on Paraoxonase 1/Arylesterase activities in patients with disorders of galactose metabolismeng
dc.typeΔημοσίευση σε περιοδικό-
heal.classificationΚλινική βιοχημεία-
heal.classificationΕνδοκρινολογία-
heal.classificationClinical biochemistry-
heal.classificationEndocrinology-
heal.classificationURI**N/A**-Κλινική βιοχημεία-
heal.classificationURI**N/A**-Ενδοκρινολογία-
heal.classificationURIhttp://id.loc.gov/authorities/subjects/sh85027062-
heal.classificationURIhttp://id.loc.gov/authorities/subjects/sh2002006108-
heal.keywordURIhttp://id.loc.gov/authorities/subjects/sh2002008729-
heal.keywordURIhttp://lod.nal.usda.gov/12712-
heal.keywordURIhttp://lod.nal.usda.gov/6219-
heal.contributorNameΤσακίρης, Στυλιανόςell
heal.identifier.secondaryDOI: 10.1111/j.1365-2265.2007.02946.x-
heal.accessfree-
heal.recordProviderΤεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Ιατρικών Εργαστηρίωνell
heal.abstractObjective  To investigate the effects of diet on the antiatherogenic enzyme Paraoxonase 1/Arylesterase (PON1/Aryl) activities in patients with disorders of galactose metabolism. Patients and methods  Eleven poorly dietary controlled children with classical galactosaemia (GALT deficiency), 7 with epimerase deficiency and 12 with duarte 1 variant ‘off diet’ underwent clinical and laboratory investigations before and after 10 days on galactose restricted diet whereas controls (N = 20) were examined once. Serum lipids, lipoproteins and apolipoprotein A1 (ApoA1) were measured with routine methods, PON1/Aryl activities and total antioxidant status (TAS) spectrophotometrically, and galactose-1-phosphate (Gal-1-P) enzymatically. Results  Lipids, lipoproteins, ApoA1, PON1/Aryl, TAS remained unaltered in all groups, except in those with classical galactosaemia pre- versus postdiet. In patients with classical galactosaemia, TAS, PON1, Aryl (0·98 ± 0·2 mmol/l, 60 ± 12 U/min/ml, 56 ± 16 KU/min/ml, respectively) were significantly reduced prediet as compared with those postdiet (1·63 ± 0·2 mmol/l, 136 ± 15 U/min/ml, 112 ± 18 KU/min/ml, respectively; P < 0·001) and controls. The enzyme activities positively correlated with TAS (r = 0·56, P < 0·001) in all groups and negatively with Gal-1-P (r = –0·54, P < 0·001) in group with GALT deficiency. Conclusions  Low TAS and high Gal-1-P levels may reduce PON1/Aryl activities. Patients with classical galactosaemia, when on strict diet, may benefit with a generous antiatherogenic capacity.en
heal.journalNameClinical Endocrinologyeng
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilitytrue-
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