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Title: Quantitative assessment of cerebral atrophy during and after treatment in children with acute lymphoblastic leukemia
Authors: Πρασόπουλος, Παναγιώτης Π.
Κάβουρας, Διονύσης Α.
Γκολφινόπουλος, Σπυρίδων
Ευλογιάς, Νικόλαος
Θεοδωρόπουλος, Βασίλης
Contributors: Παναγιώτου, Ιωάννης
Item type: Journal article
Keywords: Acute lymphoblastic leukemia;Radiotherapy;Οξεία λεμφοβλαστική λευχαιμία;Χημειοθεραπεία
Subjects: Medicine
Internal medicine
Εσωτερική παθολογία
Issue Date: 8-May-2015
Publisher: Lippincott-Raven
Abstract: RATIONALE AND OBJECTIVES: The authors evaluate quantitatively brain atrophy induced by central nervous system prophylaxis in children treated for acute lymphoblastic leukemia during and after therapy completion. METHODS: Measurements of the width of the subarachnoid compartments were performed in 243 brain computed tomography (CT) examinations of 196 children examined during (125) and/or after (71) treatment for acute lymphoblastic leukemia without central nervous system involvement. Data were compared with normative data. RESULTS: Diffuse brain atrophy was observed in 74% and 65% of the CT examinations performed during and after cessation of treatment, respectively. The highest incidence of brain atrophy (78%) occurred during the administration of intrathecal chemotherapy. All children younger than 2 years of age exhibited brain atrophy. CONCLUSIONS: Brain atrophy is the principal CT finding in the majority of children treated for acute lymphoblastic leukemia and it can be attributed mainly to intrathecal chemotherapy. This finding can be observed long after therapy completion.
Language: English
Citation: Prassopoulos, P., Cavouras, D., Golfinopoulos, S., Evlogias, E., Theodoropoulos, V., et al. (December 1996). Quantitative assessment of cerebral atrophy during and after treatment in children with acute lymphoblastic leukemia. Investigative Radiology. 31(12). pp. 749-754. Lippincott-Raven: 1996.
Journal: Investigative Radiology
Type of Journal: With a review process (peer review)
Access scheme: Embargo
License: Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες
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