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Title: Computer-based grading of haematoxylin-eosin stained tissue sections of urinary bladder carcinomas
Authors: Σπυρίδωνος, Παναγιώτα Π.
Ραβαζούλα, Παναγιώτα
Κάβουρας, Διονύσης Α.
Βερβερίδης, Κ.
Νικηφορίδης, Γεώργιος Χ.
Item type: Journal article
Keywords: Classification grading of bladder;Carcinoma;Βαθμολογική κατάταξη ουροδόχου κύστης;Καρκίνωμα
Subjects: Medicine
Biomedical engineering
Βιοϊατρική τεχνολογία
Issue Date: 8-May-2015
Publisher: Informa Healthcare
Abstract: Purpose : A computer-based image analysis system was developed for assessing the malignancy of urinary bladder carcinomas in a more objective manner. Tumours characterized in accordance with the WHO grading system were classified into low-risk (grades I and II) and high-risk (grades III and IV). Materials and methods : Images from 92 haematoxylin-eosin stained sections of urinary bladder carcinomas were digitized and analysed. An adequate number of nuclei were segmented from each image for morphologic and textural analysis. Image segmentation was performed by an efficient algorithm, which used pattern recognition methods to automatically characterize image pixels as nucleus or background. Image classification into low-risk or high-risk tumours was performed by means of the quadratic non-linear Bayesian classifier, which was designed employing 36 textural and morphological features of the nucleus. Results : Automatic segmentation of nuclei on all images was about 90% on average. Overall system accuracy in correctly classifying tumours into low-risk or high-risk was 88%, employing the leave-one-out method and the best combination of three textural and one morphological feature. Classification accuracy for low-risk tumours was 88.8% and for high-risk tumours 86.2%. Conclusion : The proposed image analysis system may be of value to the objective assessment of the malignancy of urine bladder carcinomas, since it relies on nuclear parameters that are employed in visual grading and their prognostic value has been proved.
Language: English
Citation: Spyridonos, P., Ravazoula, P., Cavouras, D., Berberidis, K. and Nikiforidis. G. (2001). Computer-based grading of haematoxylin-eosin stained tissue sections of urinary bladder carcinomas. Informatics for Health and Social Care. 26(3). pp. 179-190. Informa Healthcare : 2001.
Journal: Informatics for Health and Social Care
Type of Journal: With a review process (peer review)
Access scheme: Embargo
License: Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες
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